Research Seminar in Probability
主講者: 薛至倖女士((UC Davis) )
講題: Algorithmic computations for many 3-D virus based on low-temperature electric-microscopic image data
時間: 2012-07-23 (Mon.)  14:10 -
地點: 數學所 722 研討室 (台大院區)
Abstract: We develop a series of non-parametric computing algorithms to extract the virus structural from highly noisy data. The noise is consisting of icy-glass background and electron vs. tissue temporal interactions under low-temperature environment. Due to such an extremely low signal-to-noise ratio structure, applications of many classic Fourier and smoothing based image processing methodologies turn out unsuccessful. We illustrate our algorithmic developments through a real image example, derived from Dr. Holland Cheng's lab in UC Davis. The whole development is divided into a series of steps. Within each step, one computational challenge is addressed and its resolution is proposed, including a new SVD format for extracting reliable image signals, a hierarchical segmentation approach for further separating signal vs. noise, and a regulated random walk algorithm for drawing virus outlines. Several virus image data are also used for validity and efficiency confirmation.
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