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Seminars

Colloquium

Multi-scale methods in models of cerebral blood flow and metabolism

2024/10/24 (Thu.) 15:30~16:30
  • Date : 2024/10/24 (Thu.) 15:30~16:30
  • Location : Auditorium, 6 Floor, Institute of Mathematics (NTU Campus)
  • Speaker : Stephen Payne (Institute of Applied Mechanics, National Taiwan University)
  • Abstract : Mathematical models of cerebral blood flow and metabolism occupy a wide range of length scales (micrometres to centimetres) and time scales (seconds to decades). Although this is normally regarded as additional complexity, the range of scales offers up the possibility of exploiting multiple scales methods over both space and time (as well as validation over multiple scales). In this talk, I will present our work on building whole brain models across multiple length scales and how this can be used to simulate both health and pathology. I will also present our recent work on constructing models across multiple time scales and how this can be used to develop a model of the brain that considers effects such as ageing and hypertension, and interventions such as antihypertensive medication and exercise. I will then consider how this approach can be used in the future to consider the lifetime risk of diseases such as stroke and dementia, and the importance of clinical and lifestyle interventions to improve population brain health.
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